The WHO Advisory Group of experts on immunization strategy (SAGE) assessed the evidence that has emerged over the past few years that the single dose plan is equivalent to the two or three dose plan.

Sage’s review concluded that a single dose of human papillomavirus (HPV) vaccine provided solid protection against HPV (the virus that causes cervical cancer), comparable to the two dose regimen. This conclusion may change the rules of the game to prevent the disease; Let more girls get more doses of life-saving vaccine.

Cervical cancer is the fourth most common cancer among women in the world. Cervical cancer is often called “silent killer” and can be almost completely prevented, but it is a disease with unequal opportunities; The new sage recommendations are based on concerns about the slow introduction of HPV vaccines into immunization programmes and the low overall population coverage, especially in poorer countries.

In order to prove the protective effect of a single dose of HPV tetravalent vaccine against cervical cancer, scholars from India started a trial in 2009. More than 17000 girls aged 10-18 years were inoculated with one, two or three doses of HPV vaccine and were followed up for a long time. The results were published in the journal Lancet Oncology.

All subjects were divided into four cohorts: two dose vaccine cohort (4980 cases); 3 dose vaccine cohort (4348 cases); A cohort of 3452 patients who did not complete the scheduled plan and actually received 2 doses of vaccine; The scheduled protocol was not completed, and one dose of vaccine was actually inoculated (4949 cases). After a median follow-up of 9.0 years, the efficacy of a single dose of HPV tetravalent vaccine against persistent HPV 16/18 infection was 95.4% (95% CI 85.0 – 99.9).

Further analysis showed that for all subtypes of HPV, the effectiveness of a single dose of HPV tetravalent vaccine in preventing persistent infection was 35.4% (95% CI 3.7 – 56.0). The efficacy of two doses of HPV tetravalent vaccine was 93.1% (95% CI 77.3 – 99.8); The efficacy against persistent infection of all HPV subtypes was 36.7% (95% CI 1.6 – 57.9). The efficacy of three doses of HPV tetravalent vaccine (1460 cases) was 93.3% (95% CI 77.5 – 99.7); The efficacy against persistent infection of all HPV subtypes was 39.3% (95% CI 6.8 – 60.2).

It can be seen that the protective effect of a single dose of HPV tetravalent vaccine against persistent infection is not significantly different from that of two or three doses of HPV tetravalent vaccine. This is of great significance for reducing the cost of cervical cancer vaccine and improving the accessibility of vaccination.

In conclusion, the WHO sage expert group, after comprehensively evaluating the scientific evidence obtained in the past few years, pointed out that a single dose of HPV vaccine can provide a reliable protection equivalent to the two or three dose vaccination regimen.


1.One-dose Human Papillomavirus (HPV) vaccine offers solid protection against cervical cancer.

2.Vaccine efficacy against persistent human papillomavirus (HPV) 16/18 infection at 10 years after one, two, and three doses ofquadrivalent HPV vaccine in girls in India: a multicentre, prospective, cohortstudy. The Lancet Oncology 22.11 (2021): 1518-1529.

8 thoughts on “Who’s latest suggestion: HPV vaccine is effective even with one injection”
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