Selective serotonin transporter inhibitors, which are more effective and have fewer side effects than the previous two generations of drugs, are still the first-line antidepressant drugs in the clinic.
However, these antidepressants also have drawbacks. Failure to respond quickly: fluoxetine, for example, takes 2 to 4 weeks to take effect, which severely impedes treatment in the acute phase of severe depression.
Studies have found that such inhibitors, while they can act as antidepressants, can also induce depression. This is why antidepressants are slow to work. In turn, researchers have been searching for drugs with rapid antidepressant effects. As research continues to advance, the NMDAR blocker ketamine has entered the field of view of researchers. It has rapid antidepressant effect, but has addictive and hallucinogenic side effects. Therefore, how to find safe and fast acting antidepressant drug targets is a major scientific problem.
Based on this information, the team continued to refine, experiment, and eventually synthesize new lead compounds. And, in experiments, the new compound showed antidepressant effects just two hours after injection, a novel candidate for antidepressant drugs that act quickly. Nowadays, in the era of rapid development of medical technology, depression is not incurable disease, there must be better drugs to help people.